TriMix and tumor antigen mRNA electroporated dendritic cell vaccination plus ipilimumab: link between T-cell activation and clinical responses in advanced melanoma

BACKGROUND: We previously reported that dendritic cell-based mRNA vaccination plus ipilimumab (TriMixDC-MEL IPI) results in an encouraging rate of tumor responses in patients with pretreated advanced melanoma. Here, we report the TriMixDC-MEL IPI-induced T-cell responses detected in the peripheral b...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: De Keersmaecker, Brenda, Claerhout, Sofie, Carrasco, Javier, Bar, Isabelle, Corthals, Jurgen, Wilgenhof, Sofie, Neyns, Bart, Thielemans, Kris
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057443/
https://ncbi.nlm.nih.gov/pubmed/32114500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000329
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