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Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-X(L)()
BCL-X(L), an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival. However, the potential of BCL-X(L) as an anticancer target has been hampered by the on-target platelet toxicity because platelets depend on BCL-X(L) to maintain their viability. Here we report the development...
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| Veröffentlicht in: | Chem Commun (Camb) |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057339/ https://ncbi.nlm.nih.gov/pubmed/31754664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc07217a |
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