DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ

Diacylglycerol kinase γ (DGKγ) regulates protein kinase C (PKC) activity by converting DG to phosphatidic acid (PA). DGKγ directly interacts with PKCγ and is phosphorylated by PKCγ, resulting in the upregulation of lipid kinase activity. PKC dysfunction impairs motor coordination, indicating that th...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Tsumagari, Ryosuke, Kakizawa, Sho, Kikunaga, Sakiko, Fujihara, Yoshitaka, Ueda, Shuji, Yamanoue, Minoru, Saito, Naoaki, Ikawa, Masahito, Shirai, Yasuhito
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
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Research Article: New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057140/
https://ncbi.nlm.nih.gov/pubmed/32033984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0319-19.2020
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