Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross between two inbred strains. We re-genotyped a pr...

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Détails bibliographiques
Publié dans:G3 (Bethesda)
Auteurs principaux: Zhou, Xinzhu, St. Pierre, Celine L., Gonzales, Natalia M., Zou, Jennifer, Cheng, Riyan, Chitre, Apurva S., Sokoloff, Greta, Palmer, Abraham A.
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2020
Sujets:
Multiparental Populations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056977/
https://ncbi.nlm.nih.gov/pubmed/31974095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400763
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