Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

BACKGROUND: While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). METHODS: We...

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發表在:EBioMedicine
Main Authors: Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel, Fernández-Real, José M.
格式: Artigo
語言:Inglês
出版: Elsevier 2020
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Research paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056650/
https://ncbi.nlm.nih.gov/pubmed/32143184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102697
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