Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

BACKGROUND: While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). METHODS: We...

詳細記述

保存先:
書誌詳細
出版年:EBioMedicine
主要な著者: Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel, Fernández-Real, José M.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
Research paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056650/
https://ncbi.nlm.nih.gov/pubmed/32143184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102697
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