ARRB1-promoted NOTCH1 degradation is suppressed by oncomiR miR-223 in T cell acute lymphoblastic leukemia

T cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive leukemia with inferior prognosis. While activating mutations of NOTCH1 are observed in most T-ALL cases, these mutations alone are not sufficient to drive the full development of T-ALL. β-Arrestins (ARRBs) are versatile and multifun...

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Publicado no:Cancer Res
Main Authors: Shu, Yi, Wang, Yi, Lv, Wen-Qiong, Peng, Dan-Yi, Li, Juan, Zhang, Hang, Jiang, Guang-Jie, Yang, Bi-Jie, Liu, Shan, Zhang, Jia, Chen, Yan-Hua, Tang, Shi, Wan, Ke-Xing, Yuan, Jun-Tao, Guo, Wei, Fu, Guo, Qi, Xin-Kun, Liu, Zhi-Dai, Liu, Hai-Yan, Yang, Chao, Zhang, Ling-Huan, Liu, Fang-Jie, Yu, Jie, Zhang, Peng-Hui, Qu, Bin, Zhao, Hui, He, Tong-Chuan, Zou, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056567/
https://ncbi.nlm.nih.gov/pubmed/31822496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1471
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