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Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly

The design and creation of synthetic genomes provides a powerful approach to understanding and engineering biology. However, it is often limited by the paucity of methods for precise genome manipulation. Here, we demonstrate the programmed fission of the Escherichia coli genome into diverse pairs of...

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Bibliografische gegevens
Gepubliceerd in:Science
Hoofdauteurs: Wang, Kaihang, de la Torre, Daniel, Robertson, Wesley E., Chin, Jason W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056355/
https://ncbi.nlm.nih.gov/pubmed/31467221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0737
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