Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation

Transduction of extracellular matrix mechanics affects cell migration, proliferation, and differentiation. While this mechanotransduction is known to depend on the regulation of focal adhesion kinase phosphorylation on Y397 (FAKpY397), the mechanism remains elusive. To address this, we developed a m...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Cheng, Bo, Wan, Wanting, Huang, Guoyou, Li, Yuhui, Genin, Guy M., Mofrad, Mohammad R. K., Lu, Tian Jian, Xu, Feng, Lin, Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056303/
https://ncbi.nlm.nih.gov/pubmed/32181337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax1909
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