Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease

The influence of environmental insults on the onset and progression of mitochondrial diseases is unknown. To evaluate the effects of infection on mitochondrial disease we used a mouse model of Leigh Syndrome, where a missense mutation in the Taco1 gene results in the loss of the translation activato...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Ferreira, Nicola, Andoniou, Christopher E., Perks, Kara L., Ermer, Judith A., Rudler, Danielle L., Rossetti, Giulia, Periyakaruppiah, Ambika, Wong, Jamie K. Y., Rackham, Oliver, Noakes, Peter G., Degli-Esposti, Mariapia A., Filipovska, Aleksandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055822/
https://ncbi.nlm.nih.gov/pubmed/32130224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008604
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