PAI-1 Regulation of TGF-β1–induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages

Senescence of alveolar type II (ATII) cells, progenitors of the alveolar epithelium, is a pathological feature and contributes importantly to the pathogenesis of idiopathic pulmonary fibrosis. Despite recognition of the importance of ATII cell senescence in idiopathic pulmonary fibrosis pathogenesis...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Rana, Tapasi, Jiang, Chunsun, Liu, Gang, Miyata, Toshio, Antony, Veena, Thannickal, Victor J., Liu, Rui-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055702/
https://ncbi.nlm.nih.gov/pubmed/31513752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0071OC
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