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Stiffness of cargo-motor linkage tunes Myosin VI motility and response to load

We examine the effect of cargo-motor linkage stiffness on the mechanobiological properties of the molecular motor Myosin VI. We use the programmability of DNA nanostructures to modulate cargo-motor linkage stiffness and combine it with high precision optical trapping measurements to measure the effe...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Shrivastava, Rachit, Rai, Ashim, Salapaka, Murti, Sivaramakrishnan, Sivaraj
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055456/
https://ncbi.nlm.nih.gov/pubmed/31508940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00422
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