Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

The ability to prevent blood loss in response to injury is a conserved function of all vertebrates. Complete deficiency of the central clotting enzyme prothrombin has never been observed in humans and is incompatible with postnatal life in mice, thus limiting the ability to study its role in vivo. Z...

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Publicado no:Sci Rep
Main Authors: Grzegorski, Steven J., Hu, Zhilian, Liu, Yang, Yu, Xinge, Ferguson, Allison C., Madarati, Hasam, Friedmann, Alexander P., Reyon, Deepak, Kim, Paul Y., Kretz, Colin A., Joung, J. Keith, Shavit, Jordan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055286/
https://ncbi.nlm.nih.gov/pubmed/32132579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60840-7
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