Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation

Paclitaxel induces peripheral neuropathy as a side effect of cancer treatment. The underlying causes are unclear, but epidermal, unmyelinated axons have been shown to be the first to degenerate. We previously utilized an in vivo zebrafish model to show that the epidermal matrix-metalloproteinase 13...

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Publicado no:Sci Rep
Main Authors: Cirrincione, Anthony M., Pellegrini, Adriana D., Dominy, Jessica R., Benjamin, Marisa E., Utkina-Sosunova, Irina, Lotti, Francesco, Jergova, Stanislava, Sagen, Jacqueline, Rieger, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055229/
https://ncbi.nlm.nih.gov/pubmed/32132628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60990-8
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