Verification of EZH2 as a druggable target in metastatic uveal melanoma

BACKGROUND: Hepatic metastasis develops in ~ 50% of uveal melanoma (UM) patients with no effective treatments. Although GNAQ/GNA11 mutations are believed to confer pathogenesis of UM, the underlying mechanism of liver metastasis remains poorly understood. Given that profound epigenetic evolution may...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Jin, Bei, Zhang, Ping, Zou, Hailin, Ye, Huijing, Wang, Yun, Zhang, Jing, Yang, Huasheng, Pan, Jingxuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055080/
https://ncbi.nlm.nih.gov/pubmed/32127003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01173-x
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