Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

BACKGROUND: We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role of Parkin-mediated mitophagy in the protective effects of PD in SI-AKI in mice....

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Bibliographic Details
Published in:J Transl Med
Main Authors: Gao, Youguang, Dai, Xingui, Li, Yunfeng, Li, Guicheng, Lin, Xianzhong, Ai, Chenmu, Cao, Yuanyuan, Li, Tao, Lin, Bo
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055075/
https://ncbi.nlm.nih.gov/pubmed/32131850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02283-2
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