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Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

Mitochondrial dysfunction promotes metabolic stress responses in a cell‐autonomous as well as organismal manner. The wasting hormone growth differentiation factor 15 (GDF15) is recognized as a biomarker of mitochondrial disorders, but its pathophysiological function remains elusive. To test the hypo...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Ost, Mario, Igual Gil, Carla, Coleman, Verena, Keipert, Susanne, Efstathiou, Sotirios, Vidic, Veronika, Weyers, Miriam, Klaus, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054681/
https://ncbi.nlm.nih.gov/pubmed/32026535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948804
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