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Mathematical modeling and parameter estimation of levodopa motor response in patients with parkinson disease

Parkinson disease (PD) is characterized by a clear beneficial motor response to levodopa (LD) treatment. However, with disease progression and longer LD exposure, drug-related motor fluctuations usually occur. Recognition of the individual relationship between LD concentration and its effect may be...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ursino, Mauro, Magosso, Elisa, Lopane, Giovanna, Calandra-Buonaura, Giovanna, Cortelli, Pietro, Contin, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053720/
https://ncbi.nlm.nih.gov/pubmed/32126124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229729
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