Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats

Osteoarthritis (OA) is a chronic degenerative joint disease, related to the overexpression of matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), inflammation, and chondrocyte apoptosis. Nesfatin-1 is an adipokine, which plays an important role...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Jiang, Lifeng, Xu, Kai, Li, Jin, Zhou, Xindie, Xu, Langhai, Wu, Zhipeng, Ma, Chiyuan, Ran, Jisheng, Hu, Pengfei, Bao, Jiapeng, Wu, Lidong, Xiong, Yan
Format: Artigo
Language:Inglês
Published: Impact Journals 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053635/
https://ncbi.nlm.nih.gov/pubmed/32003758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102711
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