MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma

In this study, we identified microRNAs that regulate the expression of programmed death-ligand 1(PD-L1) in osteosarcoma and investigated their role in PD-L1-targeted immunotherapy. MicroRNA sequencing analysis showed that the expression of PD-L1 is regulated by microRNA-200a in U2OS, 143B, and K7 os...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Liu, Zhuochao, Wen, Junxiang, Wu, Chuanlong, Hu, Chuanzhen, Wang, Jun, Bao, Qiyuan, Wang, Hongyi, Wang, Jizhuang, Zhou, Qi, Wei, Li, Shen, Yuhui, Zhang, Weibin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053609/
https://ncbi.nlm.nih.gov/pubmed/31981455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102679
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