Super-Resolution Whole-Brain 3D MR Spectroscopic Imaging for Mapping D-2-Hydroxyglutarate and Tumor Metabolism in Isocitrate Dehydrogenase 1–mutated Human Gliomas

BACKGROUND: Isocitrate dehydrogenase (IDH) mutations are highly frequent in glioma, producing high levels of the oncometabolite D-2-hydroxyglutarate (D-2HG). Hence, D-2HG represents a valuable imaging marker for IDH-mutated human glioma. PURPOSE: To develop and evaluate a super-resolution three-dime...

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Bibliographische Detailangaben
Veröffentlicht in:Radiology
Hauptverfasser: Li, Xianqi, Strasser, Bernhard, Jafari-Khouzani, Kourosh, Thapa, Bijaya, Small, Julia, Cahill, Daniel P., Dietrich, Jorg, Batchelor, Tracy T., Andronesi, Ovidiu C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Radiological Society of North America 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053225/
https://ncbi.nlm.nih.gov/pubmed/31909698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/radiol.2020191529
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