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Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression
In this study, we use an optogenetic inhibitor of c-Jun NH(2)-terminal kinase (JNK) in dendritic spine sub-compartments of rat hippocampal neurons. We show that JNK inhibition exerts rapid (within seconds) reorganization of actin in the spine-head. Using real-time Förster resonance energy transfer (...
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| Pubblicato in: | eNeuro |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7053173/ https://ncbi.nlm.nih.gov/pubmed/31937523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0303-19.2019 |
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