MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 component) binding and envelopment. Nevertheless, the u...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Kumar, Sathish, Barouch-Bentov, Rina, Xiao, Fei, Schor, Stanford, Pu, Szuyuan, Biquand, Elise, Lu, Albert, Lindenbach, Brett D., Jacob, Yves, Demeret, Caroline, Einav, Shirit
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053169/
https://ncbi.nlm.nih.gov/pubmed/30759391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.075
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