Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors

Oncogene-addicted cancers are predominantly driven by specific oncogenic pathways and display initial exquisite sensitivity to designer therapies, but eventually become refractory to treatments. Clear understanding of lung tumorigenic mechanisms is essential for improved therapies. Methods: Lysosome...

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Udgivet i:Theranostics
Main Authors: Chin, Tan-Min, Boopathy, Gandhi T. K., Man, Ellen P.S., Clohessy, John G., Csizmadia, Eva, Quinlan, Margaret P, Putti, Thomas, Wan, Seow-Ching, Xie, Chen, Ali, Azhar, Wai, Fhu Chee, Ong, Yan Shan, Goh, Boon-Cher, Settleman, Jeff, Hong, Wanjin, Levantini, Elena, Tenen, Daniel G.
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052910/
https://ncbi.nlm.nih.gov/pubmed/32194831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.38729
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