Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion

Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these events remains unclear. Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a master regulator for mitochondrial function. This study...

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Publicado en:Theranostics
Autores principales: Han, Bin, Jiang, Wei, Liu, Haijie, Wang, Junjie, Zheng, Kai, Cui, Pan, Feng, Yan, Dang, Chun, Bu, Yali, Wang, Qing Mei, Ju, Zhenyu, Hao, Junwei
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052889/
https://ncbi.nlm.nih.gov/pubmed/32194838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.37119
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