Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion

Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these events remains unclear. Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a master regulator for mitochondrial function. This study...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Han, Bin, Jiang, Wei, Liu, Haijie, Wang, Junjie, Zheng, Kai, Cui, Pan, Feng, Yan, Dang, Chun, Bu, Yali, Wang, Qing Mei, Ju, Zhenyu, Hao, Junwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052889/
https://ncbi.nlm.nih.gov/pubmed/32194838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.37119
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