Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia

Preeclampsia (PE) is characterized by new-onset hypertension that usually occurs in the third trimester of pregnancy and is associated with oxidative stress and angiotensin II type 1 receptor agonistic autoantibodies (AT(1)-AAs). Inhibition of the AT(1)-AAs in the reduced uterine perfusion pressure...

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Gepubliceerd in:Am J Physiol Regul Integr Comp Physiol
Hoofdauteurs: Vaka, Venkata Ramana, Cunningham, Mark W., Deer, Evangeline, Franks, Michael, Ibrahim, Tarek, Amaral, Lorena M., Usry, Nathan, Cornelius, Denise C., Dechend, Ralf, Wallukat, Gerd, LaMarca, Babbette D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052605/
https://ncbi.nlm.nih.gov/pubmed/31721604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00179.2019
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