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Predicting the impacts of mutations on protein-ligand binding affinity based on molecular dynamics simulations and machine learning methods
PURPOSE: Mutation-induced variation of protein-ligand binding affinity is the key to many genetic diseases and the emergence of drug resistance, and therefore predicting such mutation impacts is of great importance. In this work, we aim to predict the mutation impacts on protein-ligand binding affin...
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| Yayımlandı: | Comput Struct Biotechnol J |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Research Network of Computational and Structural Biotechnology
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7052406/ https://ncbi.nlm.nih.gov/pubmed/32153730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.02.007 |
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