Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Sun, Yueshan, Jiang, Xueqin, Pan, Rong, Zhou, Xiaogang, Qin, Dalian, Xiong, Rui, Wang, Yiling, Qiu, Wenqiao, Wu, Anguo, Wu, Jianming
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052340/
https://ncbi.nlm.nih.gov/pubmed/32158393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00116
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