Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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Publicado en:Front Pharmacol
Main Authors: Sun, Yueshan, Jiang, Xueqin, Pan, Rong, Zhou, Xiaogang, Qin, Dalian, Xiong, Rui, Wang, Yiling, Qiu, Wenqiao, Wu, Anguo, Wu, Jianming
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052340/
https://ncbi.nlm.nih.gov/pubmed/32158393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00116
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