Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence. However, the role of this Nef function in virus-mediated immune activation and pathogenicity remains speculative. Here, we selectiv...

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Publicado en:Cell Rep
Autores principales: Joas, Simone, Sauermann, Ulrike, Roshani, Berit, Klippert, Antonina, Daskalaki, Maria, Mätz-Rensing, Kerstin, Stolte-Leeb, Nicole, Heigele, Anke, Tharp, Gregory K., Mehrotra Gupta, Prachi, Nelson, Sydney, Bosinger, Steven, Parodi, Laura, Giavedoni, Luis, Silvestri, Guido, Sauter, Daniel, Stahl-Hennig, Christiane, Kirchhoff, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052273/
https://ncbi.nlm.nih.gov/pubmed/32075764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.069
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