Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor–Positive, Early Breast Cancer

BACKGROUND: EarlyR gene signature in estrogen receptor–positive (ER+) breast cancer is computed from the expression values of ESPL1, SPAG5, MKI67, PLK1, and PGR. EarlyR has been validated in multiple cohorts profiled using microarrays. This study sought to verify the prognostic features of EarlyR in...

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Publicado en:JNCI Cancer Spectr
Main Authors: Buechler, Steven A, Gray, Kathryn P, Gökmen-Polar, Yesim, Willis, Scooter, Thürlimann, Beat, Kammler, Rosita, Viale, Giuseppe, Leyland-Jones, Brian, Badve, Sunil S, Regan, Meredith M
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049990/
https://ncbi.nlm.nih.gov/pubmed/32337480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkz051
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