Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals

BACKGROUND: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells. However, its exact role in proviral transcriptional reg...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Kint, Sam, Trypsteen, Wim, De Spiegelaere, Ward, Malatinkova, Eva, Kinloch-de Loes, Sabine, De Meyer, Tim, Van Criekinge, Wim, Vandekerckhove, Linos
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049218/
https://ncbi.nlm.nih.gov/pubmed/32111236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00829-1
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