Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Little is known regarding lymph node (LN)-homing of immune cells via afferent lymphatics. Here, we show, using a photo-convertible Dendra-2 reporter, that recently activated CD4 T cells enter downstream LNs via afferent lymphatics at high frequencies. Intra-lymphatic immune cell transfer and live im...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Martens, Rieke, Permanyer, Marc, Werth, Kathrin, Yu, Kai, Braun, Asolina, Halle, Olga, Halle, Stephan, Patzer, Gwendolyn E., Bošnjak, Berislav, Kiefer, Friedemann, Janssen, Anika, Friedrichsen, Michaela, Poetzsch, Jenny, Kohli, Karan, Lueder, Yvonne, Gutierrez Jauregui, Rodrigo, Eckert, Nadine, Worbs, Tim, Galla, Melanie, Förster, Reinhold
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048855/
https://ncbi.nlm.nih.gov/pubmed/32111837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14921-w
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