High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-reso...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Dian, Cyril, Pérez-Dorado, Inmaculada, Rivière, Frédéric, Asensio, Thomas, Legrand, Pierre, Ritzefeld, Markus, Shen, Mengjie, Cota, Ernesto, Meinnel, Thierry, Tate, Edward W., Giglione, Carmela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048800/
https://ncbi.nlm.nih.gov/pubmed/32111831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14847-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi