High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-reso...

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Vydáno v:Nat Commun
Hlavní autoři: Dian, Cyril, Pérez-Dorado, Inmaculada, Rivière, Frédéric, Asensio, Thomas, Legrand, Pierre, Ritzefeld, Markus, Shen, Mengjie, Cota, Ernesto, Meinnel, Thierry, Tate, Edward W., Giglione, Carmela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048800/
https://ncbi.nlm.nih.gov/pubmed/32111831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14847-3
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