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Single-molecule imaging of PI(4,5)P(2) and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding

PTEN, a 3-phosphatase of phosphoinositide, regulates asymmetric PI(3,4,5)P(3) signaling for the anterior-posterior polarization and migration of motile cells. PTEN acts through posterior localization on the plasma membrane, but the mechanism for this accumulation is poorly understood. Here we develo...

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Bibliografiske detaljer
Udgivet i:Commun Biol
Main Authors: Yoshioka, Daisuke, Fukushima, Seiya, Koteishi, Hiroyasu, Okuno, Daichi, Ide, Toru, Matsuoka, Satomi, Ueda, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048775/
https://ncbi.nlm.nih.gov/pubmed/32111929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0818-3
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