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Single-molecule imaging of PI(4,5)P(2) and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding
PTEN, a 3-phosphatase of phosphoinositide, regulates asymmetric PI(3,4,5)P(3) signaling for the anterior-posterior polarization and migration of motile cells. PTEN acts through posterior localization on the plasma membrane, but the mechanism for this accumulation is poorly understood. Here we develo...
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| Izdano u: | Commun Biol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7048775/ https://ncbi.nlm.nih.gov/pubmed/32111929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0818-3 |
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