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Neonatal immune challenge followed by adult immune challenge induces epigenetic-susceptibility to aggravated visceral hypersensitivity

BACKGROUND: Abdominal pain is one of the major symptoms of inflammatory Bowel Disease (IBD). The inflammatory mediators released by colon inflammation are known to sensitize the afferent neurons, which is one of the contributors to abdominal pain. However, not all IBD patients have abdominal pain, a...

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Vydáno v:Neurogastroenterol Motil
Hlavní autoři: Aguirre, Jose E, Winston, John H., Sarna, Sushil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048321/
https://ncbi.nlm.nih.gov/pubmed/28439935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.13081
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