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Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

The DNA/RNA processing protein TDP-43 undergoes both functional and pathogennic aggregation. Functional TDP-43 aggregates form reversible, transient species such as nuclear bodies, stress granules, and myo-granules. Pathogenic, irreversible TDP-43 aggregates form in amyotrophic lateral sclerosis (AL...

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Publicat a:Nat Struct Mol Biol
Autors principals: Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047951/
https://ncbi.nlm.nih.gov/pubmed/31235914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0248-4
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