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Gene regulatory strategies that decode the duration of NFκB dynamics contribute to LPS- vs. TNF-specific gene expression

Pathogen-derived lipopolysaccharide (LPS) and cytokine tumor necrosis factor (TNF) activate NFκB with distinct duration dynamics, but how immune response genes decode NFκB duration to produce stimulus-specific expression remains unclear. Here, detailed transcriptomic profiling of combinatorial and t...

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Publicat a:Cell Syst
Autors principals: Sen, Supriya, Cheng, Zhang, Sheu, Katherine M, Chen, Yu Hsin, Hoffmann, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047529/
https://ncbi.nlm.nih.gov/pubmed/31972132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.12.004
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