Rare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset Severe Obesity

Context: The hypothalamic circuit has an essential role in the regulation of appetite and energy expenditure. Pathogenic variants in genes involved in the hypothalamic leptin–melanocortin pathway, including melanocortin-4-receptor (MC4R), have been associated with monogenic obesity. Objective: To de...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Loid, Petra, Mustila, Taina, Mäkitie, Riikka E., Viljakainen, Heli, Kämpe, Anders, Tossavainen, Päivi, Lipsanen-Nyman, Marita, Pekkinen, Minna, Mäkitie, Outi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047210/
https://ncbi.nlm.nih.gov/pubmed/32153512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.00081
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