FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy

BACKGROUND: Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including lung cancer, and was initially focused on FGFR1-amplified...

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Udgivet i:EBioMedicine
Main Authors: Quintanal-Villalonga, Álvaro, Ferrer, Irene, Guruceaga, Elizabeth, Cirauqui, Cristina, Marrugal, Ángela, Ojeda, Laura, García, Santiago, Zugazagoitia, Jon, Muñoz-Galván, Sandra, Lopez-Rios, Fernando, Montuenga, Luis, Vicent, Silvestre, Molina-Pinelo, Sonia, Carnero, Amancio, Paz-Ares, Luis
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047190/
https://ncbi.nlm.nih.gov/pubmed/32114392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102683
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