Neuron-specific knockdown of solute carrier protein SLC25A46a induces locomotive defects, an abnormal neuron terminal morphology, learning disability, and shortened lifespan

Various mutations in the SLC25A46 gene have been reported in mitochondrial diseases that are sometimes classified as type 2 Charcot-Marie-Tooth disease, optic atrophy, and Leigh syndrome. Although human SLC25A46 is a well-known transporter that acts through the mitochondrial outer membrane, the rela...

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Bibliographische Detailangaben
Veröffentlicht in:IBRO Rep
Hauptverfasser: Ali, Md Saheb, Suda, Kojiro, Kowada, Ryosuke, Ueoka, Ibuki, Yoshida, Hideki, Yamaguchi, Masamitsu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047145/
https://ncbi.nlm.nih.gov/pubmed/32140609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibror.2020.02.001
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