Knockdown of the Drosophila Fused in Sarcoma (FUS) Homologue Causes Deficient Locomotive Behavior and Shortening of Motoneuron Terminal Branches

Mutations in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS, FUS) have been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). FUS is an RNA-binding protein that is normally localized in the nucleus, but is mislocalized to the cytoplasm in ALS, and compri...

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Autori principali: Sasayama, Hiroshi, Shimamura, Mai, Tokuda, Takahiko, Azuma, Yumiko, Yoshida, Tomokatsu, Mizuno, Toshiki, Nakagawa, Masanori, Fujikake, Nobuhiro, Nagai, Yoshitaka, Yamaguchi, Masamitsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378546/
https://ncbi.nlm.nih.gov/pubmed/22724023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039483
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