Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

OBJECTIVE: In utero exposure of the fetus to Ro/La autoantibodies may lead to congenital heart block (CHB). In the mother, these autoantibodies are associated with activation of the type I interferon (IFN)-system. As maternal autoantibodies are transferred to the fetus during pregnancy, we investiga...

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Veröffentlicht in:RMD Open
Hauptverfasser: Hedlund, Malin, Thorlacius, Gudny Ella, Ivanchenko, Margarita, Ottosson, Vijole, Kyriakidis, Nikolaos, Lagnefeldt, Linda, Tingström, Joanna, Sirsjö, Allan, Bengtsson, Anders A, Aronsson, Emma, Gemzell-Danielsson, Kristina, Ronnblom, Lars, Bergman, Gunnar, Espinosa, Alexander, Sonesson, Sven-Erik, Eloranta, Maija-Leena, Wahren-Herlenius, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Sjögren Syndrome
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046945/
https://ncbi.nlm.nih.gov/pubmed/31958275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2019-000989
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