Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block

Congenital heart block develops in fetuses after placental transfer of Ro/SSA autoantibodies from rheumatic mothers. The condition is often fatal and the majority of live-born children require a pacemaker at an early age. The specific antibody that induces the heart block and the mechanism by which...

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Bibliografiske detaljer
Main Authors: Salomonsson, Stina, Sonesson, Sven-Erik, Ottosson, Lars, Muhallab, Saad, Olsson, Tomas, Sunnerhagen, Maria, Kuchroo, Vijay K., Thorén, Peter, Herlenius, Eric, Wahren-Herlenius, Marie
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212767/
https://ncbi.nlm.nih.gov/pubmed/15630133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041859
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