Dynamics Rationalize Proteolytic Susceptibility of the Major Birch Pollen Allergen Bet v 1

Proteolytic susceptibility during endolysosomal degradation is decisive for allergic sensitization. In the major birch pollen allergen Bet v 1 most protease cleavage sites are located within its secondary structure elements, which are inherently inaccessible to proteases. The allergen thus must unfo...

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Bibliographic Details
Published in:Front Mol Biosci
Main Authors: Kamenik, Anna S., Hofer, Florian, Handle, Philip H., Liedl, Klaus R.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Molecular Biosciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045072/
https://ncbi.nlm.nih.gov/pubmed/32154264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00018
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