A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity

HIV-1-induced cytopathicity of thymocytes is a major cause of reduced peripheral T cells and rapid disease progression observed in HIV-1-infected infants. Understanding the virulence factors responsible for thymocyte depletion has paramount importance in addressing the pathogenesis of disease progre...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Ali, Ayub, Furler, Robert L., Pedroza-Martins, Livia, Colantonio, Arnaud D., Anisman-Posner, Deborah, Bryson, Yvonne, Yang, Otto O., Uittenbogaart, Christel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044772/
https://ncbi.nlm.nih.gov/pubmed/31571497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2019.0160
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