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CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons

BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming a transcriptional positive feedback loop. In the current study, we have inv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Esvald, Eli-Eelika, Tuvikene, Jürgen, Sirp, Alex, Patil, Sudarshan, Bramham, Clive R., Timmusk, Tõnis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044735/
https://ncbi.nlm.nih.gov/pubmed/31915257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0367-19.2019
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