NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Lysine fatty acylation in mammalian cells was discovered nearly three decades ago, yet the enzymes catalyzing it remain unknown. Unexpectedly, we find that human N-terminal glycine myristoyltransferases (NMT) 1 and 2 can efficiently myristoylate specific lysine residues. They modify ADP-ribosylation...

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Udgivet i:Nat Commun
Main Authors: Kosciuk, Tatsiana, Price, Ian R., Zhang, Xiaoyu, Zhu, Chengliang, Johnson, Kayla N., Zhang, Shuai, Halaby, Steve L., Komaniecki, Garrison P., Yang, Min, DeHart, Caroline J., Thomas, Paul M., Kelleher, Neil L., Fromme, J. Christopher, Lin, Hening
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044312/
https://ncbi.nlm.nih.gov/pubmed/32103017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14893-x
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